Affiliation:
1. School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong
2. The Key Laboratory of Pharmacology and Druggability for Natural Medicines of Department of Education, Guizhou Province, Guizhou Medical University, 550025 Guizhou, China
Abstract
Inflammatory bowel disease (IBD) is an uncontrolled chronic inflammatory intestinal
disorder, which requires medications for long-term therapy. Facing the challenges
of severe side effects and drug resistance of conventional medications, to develop the
strategies meet the stringent safety and effectiveness in the long-term treatment are urgent
in the clinics. In this regard, a growing body of evidence confirms plant-sourced phenols,
such as flavonoids, catechins, stilbenes, coumarins, quinones, lignans, phenylethanoids,
cannabinoid phenols, tannins, phenolic acids and hydroxyphenols, exert potent protective
benefits with fewer undesirable effects in conditions of acute or chronic intestinal inflammation
through improvement of colonic oxidative and pro-inflammatory status,
preservation of the epithelial barrier function and modulation of gut microbiota. In this
review, the great potential of plant-sourced phenols and their action mechanisms for the
treatment or prevention of IBD in recent research are summarized, which may help further
development of new preventive/adjuvant regimens for IBD.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
29 articles.
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