Affiliation:
1. Laboratory of Bioactive Research and Development (LIDeB), Faculty of Exact Sciences, University of La Plata (UNLP), La Plata, Argentina
Abstract
:
Chagas disease is an infectious tropical disease included within the group of neglected tropical
diseases. Though historically endemic to Latin America, it has lately spread to high-income countries
due to human migration. At present, there are only two available drugs, nifurtimox and benznidazole,
approved for this treatment, both with considerable side-effects (which often result in treatment
interruption) and limited efficacy in the chronic stage of the disease in adults.
:
Drug repositioning involves finding novel therapeutic indications for known drugs, including approved,
withdrawn, abandoned and investigational drugs. It is today a broadly applied approach to develop
innovative medications, since indication shifts are built on existing safety, ADME and manufacturing
information, thus greatly shortening development timeframes. Drug repositioning has been signaled as
a particularly interesting strategy to search for new therapeutic solutions for neglected and rare conditions,
which traditionally present limited commercial interest and are mostly covered by the public
sector and not-for-profit initiatives and organizations.
:
Here, we review the applications of computer-aided technologies as systematic approaches to drug
repositioning in the field of Chagas disease. In silico screening represents the most explored approach,
whereas other rational methods such as network-based and signature-based approximations have still
not been applied.
Funder
Argentinean National Agency of Scientific and Technical Research
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
11 articles.
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