Lipid Nanoparticles and Active Natural Compounds: A Perfect Combination for Pharmaceutical Applications-Reference-Cited by-同舟云学术

Lipid Nanoparticles and Active Natural Compounds: A Perfect Combination for Pharmaceutical Applications

Published:2019-10-11 Issue:24 Volume:26 Page:4681-4696
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Puglia Carmelo¹,Pignatello Rosario¹,Fuochi Virginia²,Furneri Pio Maria²,Lauro Maria Rosaria³,Santonocito Debora¹,Cortesi Rita⁴,Esposito Elisabetta⁴

Affiliation:

1. Department of Drug Sciences, University of Catania, Catania, Italy

2. Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy

3. Department of Pharmacy, University of Salerno, Fisciano (SA), Italy

4. Department of Life Sciences and Biotechnologies, University of Ferrara, Ferrara, Italy

Abstract

Phytochemicals represent an important class of bioactive compounds characterized by significant health benefits. Notwithstanding these important features, their potential therapeutic properties suffer from poor water solubility and membrane permeability limiting their approach to nutraceutical and pharmaceutical applications. Lipid nanoparticles are well known carrier systems endowed with high biodegradation and an extraordinary biocompatible chemical nature, successfully used as platform for advanced delivery of many active compounds, including the oral, topical and systemic routes. This article is aimed at reviewing the last ten years of studies about the application of lipid nanoparticles in active natural compounds reporting examples and advantages of these colloidal carrier systems.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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