Tanshinones: An Update in the Medicinal Chemistry in Recent 5 Years-Reference-Cited by-同舟云学术

Tanshinones: An Update in the Medicinal Chemistry in Recent 5 Years

Published:2021-05-28 Issue:14 Volume:28 Page:2807-2827
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Lai Zhencheng¹^ORCID,He Jixiao¹^ORCID,Zhou Changxin²^ORCID,Zhao Huajun³^ORCID,Cui Sunliang¹^ORCID

Affiliation:

1. Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

2. Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

3. College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China

Abstract

Tanshinones are an important type of natural products isolated from Salvia miltiorrhiza Bunge with various bioactivities. Tanshinone IIa, cryptotanshinone and tanshinone I are three kinds of tanshinones which have been widely investigated. Particularly, sodium tanshinone IIa sulfonate is a water-soluble derivative of tanshinone IIa and it is used in clinical in China for treating cardiovascular diseases. In recent years, there are increasing interests in the investigation of tanshinones derivatives in various diseases. This article presents a review of the anti-atherosclerotic effects, cardioprotective effects, anticancer activities, antibacterial activities and antiviral activities of tanshinones and structural modification work in recent years.

Funder

Zhejiang Chinese Medical University

National Natural Science Foundation of China

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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