Catalyst-Free Glycerol Promoted Green Synthesis of 2-amino-1,8- naphthyridine -3-carbonitriles and 2-amino-3-quinolinecarbonitriles

Abstract

We describe herein the use of glycerol as an efficient and sustainable approach for the synthesis of 2-amino-1, 8-naphthyridine-3-carbonitriles and 2-amino-3-quinolinecarbonitriles. The catalyst- free reactions occur straightforwardly using biodegradable and non-hazardous solvent. It is a strategy to address mounting environmental concerns with current approach includes the use of environmentally benign solvent, simple workup procedure, economic viability, shorter reaction time and providing good to excellent yield.