Affiliation:
1. School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, P.R. China
2. Department of
Pharmacy, First Affiliated Hospital of Dalian Medical University, Dalian, P.R. China
Abstract
Objective:
This study aims to investigate the main metabolites and metabolic pathways
of Portulacatone B in rats, which is an alkaloid isolated from Portulaca oleracea L.
Methods:
Portulacatone B was administered through the tail vein of the rat, and the orbital blood
at 10 and 30 min and urine and feces within 24 h were collected. The metabolites and metabolic
pathways in the rat were researched by ultra-high performance liquid chromatographyelectrospray
coupled with quadrupole-time of flight mass spectrometry (UHPLC-ESI-QTOF/
MS).
Results:
The research results of the metabolites and metabolic pathways of Portulacatone B
showed that after administration through the tail vein of rats, 3 metabolites were found in the
plasma sample, 2 metabolites in the urine sample, and one metabolite in the feces sample. The
main metabolic pathways were found to be oxidation, hydrolysis, methylation, glucuronidation,
and sulfonation.
Conclusion:
Six metabolites were found in the rat’s plasma, urine, and feces samples, and the
metabolic pathways included oxidation, hydrolysis, methylation, glucuronidation, and sulfonation
process.
Funder
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Molecular Medicine,Biochemistry,Biophysics
Cited by
1 articles.
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