Affiliation:
1. Department of Pharmacy, Raj Kumar Goel Institute of Technology (Pharmacy), 5-Km. Stone, Delhi-Meerut Road,
Ghaziabad, Uttar Pradesh, 201003, India
Abstract
Abstract:
Administering therapeutics through the oral route is a pervasive and widely approved
medication administration approach. However, it has been found that many drugs show low systemic
absorption when delivered through this route. Such limitations of oral drug delivery can be
overcome by polymeric micelles acting as vehicles. As a result, they improve drug absorption by
protecting loaded drug substances from the gastrointestinal system's hostile conditions, allowing
controlled drug release at a specific site, extending the time spent in the gut through mucoadhesion,
and inhibiting the efflux pump from reducing therapeutic agent accumulation. To promote good
oral absorption of a weakly water-soluble medicinal drug, the loaded medicine should be protected
from the hostile atmosphere of the GI tract. Polymeric micelles can be stacked with a broad assortment
of ineffectively dissolvable medications, improving bioavailability. This review discusses
the major mechanism, various types, advantages, and limitations for developing the polymeric micelle
system and certain micellar drug delivery system applications. The primary goal of this
review is to illustrate how polymeric micelles can be used to deliver poorly water-soluble medications.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Pharmacology,Toxicology
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