Affiliation:
1. School of Basic Medical Sciences, Kunming Medical University, Kunming Yunnan 650500,China
Abstract
In recent years, bioactive peptide drugs have attracted growing attention due to the increasing
difficulty in developing new drugs with novel chemical structures. In addition, many diseases
are linked to excessive oxidation in the human body. Therefore, the role of peptides with antioxidant
activity in counteracting diseases related to oxidative stress is worth exploring. Amphibians
are a major repository for bioactive peptides that protect the skin from biotic and abiotic
stresses, such as microbial infection and radiation injury. We characterized the first amphibian-
derived gene-encoded antioxidant peptides in 2008. Since then, a variety of antioxidant
peptides have been detected in different amphibian species. In this work, the physicochemical properties
of antioxidant peptides identified from amphibians are reviewed for the first time, particularly
acquisition methods, amino acid characteristics, antioxidant mechanisms, and application
prospects. This review should provide a reference for advancing the identification, structural analysis,
and potential therapeutic value of natural antioxidant peptides.
Funder
Chinese National Natural Science Foundation
Natural Science Foundation of Yunnan Province
Publisher
Bentham Science Publishers Ltd.
Subject
Biochemistry,General Medicine,Structural Biology
Cited by
11 articles.
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