Affiliation:
1. Department of Biopharmaceutical Sciences, College of Pharmaceutical Sciences Soochow University Suzhou Jiangsu China
2. National University of Singapore (Suzhou) Research Institute Suzhou Jiangsu China
3. Department of Food Science and Technology, Food Science and Technology Center National University of Singapore Singapore Singapore
4. Department of Bioscience and Biotechnology Dalian University of Technology Dalian Liaoning China
Abstract
AbstractReactive oxygen species (ROS) are produced during oxidative metabolism in aerobic organisms. Under normal conditions, ROS production and elimination are in a relatively balanced state. However, under internal or external environmental stress, such as high glucose levels or UV radiation, ROS production can increase significantly, leading to oxidative stress. Excess ROS production not only damages biomolecules but is also closely associated with the pathogenesis of many diseases, such as skin photoaging, diabetes, and cancer. Antioxidant peptides (AOPs) are naturally occurring or artificially designed peptides that can reduce the levels of ROS and other pro‐oxidants, thus showing great potential in the treatment of oxidative stress‐related diseases. In this review, we discussed ROS production and its role in inducing oxidative stress‐related diseases in humans. Additionally, we discussed the sources, mechanism of action, and evaluation methods of AOPs and provided directions for future studies on AOPs.
Funder
National Natural Science Foundation of China
Subject
Drug Discovery,Pharmacology,Molecular Medicine
Cited by
32 articles.
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