Anticancer Mechanisms of Bioactive Peptides-Reference-Cited by-同舟云学术

Anticancer Mechanisms of Bioactive Peptides

Published:2020-10-14 Issue:9 Volume:27 Page:823-830
ISSN:0929-8665
Container-title:Protein & Peptide Letters
language:en
Short-container-title:PPL

Author:

Soon Tsuey Ning¹,Chia Adeline Yoke Yin¹,Yap Wei Hsum¹^ORCID,Tang Yin-Quan¹^ORCID

Affiliation:

1. School of Biosciences, Faculty of Medical and Health Sciences, Taylor’s University, 47500 Subang Jaya, Selangor Darul Ehsan, Malaysia

Abstract

: Despite technological advancement, there is no 100% effective treatment against metastatic cancer. Increasing resistance of cancer cells towards chemotherapeutic drugs along with detrimental side effects remained a concern. Thus, the urgency in developing new anticancer agents has been raised. Anticancer peptides have been proven to display potent activity against a wide variety of cancer cells. Several mode of actions describing their cytostatic and cytotoxic effect on cancer cells have been proposed which involves cell surface binding leading to membranolysis or internalization to reach their intracellular target. Understanding the mechanism of action of these anticancer peptides is important in achieving full therapeutic success. In the present article, we discuss the anticancer action of peptides accompanied by the mechanisms underpinning their toxicity to cancer cells.

Funder

Taylor’s Research

Publisher

Bentham Science Publishers Ltd.

Subject

Biochemistry,General Medicine,Structural Biology

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