Microwave-Induced Expeditious Synthesis of Biologically Active Substituted Imidazoles using CuO-TiO2-GO Nanocomposite as a Recyclable Catalyst

Abstract

An efficient, green and rapid protocol for one-pot synthesis of substituted imidazoles from isatin, aryl/hetero-aryl aldehydes and ammonium acetate in presence of CuO-TiO2-GO nanocomposite as catalyst under microwave irradiation has been reported in this article. The CuO-TiO2-GO nanocomposite was synthesized by the hydrothermal method. Further, the prepared composite was characterized by FT-IR, XRD, FESEM, EDS, TEM, Raman and TGA techniques. The protocol offered several advantages such as high rate of reaction, excellent yields, economic feasibility, simple work-up and reusability of catalyst up to six cycles. Further antimicrobial activities of the synthesized substituted imidazoles were evaluated by the broth dilution method.