Therapeutic Potential of a Bioactive Flavonoids Glycitin from Glycine max: A Review on Medicinal Importance, Pharmacological Activities and Analytical Aspects

Abstract

Background: Soybean (Glycine max (L.) Merr.) is an important industrial crop and fourth major crop in the world which are the richest source of isofavones including glycitein in human diet. Soybean has been associated with beneficial effects in prevention of cancer, osteoporosis, cardiovascular diseases and menopausal symptoms. Isoflavones class phytochemicals has been extensively studied in the scientific fields due to its estrogenic potential. Methods: Scientific information of glycitin for their biological potential and therapeutic effects has been collected and analyzed in the present work. Scientific data of glycitin has been collected from electronic databases such as Google, Google Scholar, PubMed, Science Direct, and Scopus in the present work and analyzed for their therapeutic potential. Detailed pharmacological activities and analytical data of glycitin has been collected from these databases using term flavonoid and glycitin and analyzed. Results: Scientific data analysis revealed the biological importance and therapeutic benefit of glycitin in the medicine. Glycitin also called 4′-hydroxy-6-methoxyisoflavone-7-D-glucoside have been found to present in the Soy products. Glycitin exhibit chemo-preventive, cardio-protective and anti-osteoporosis effects. Glycitin revealed their beneficial effects on diabetes, acute lung injury, bone, cognitive performance, breast cancer, skin, immune system, enzymes, prostaglandin and taste receptors. However its ligand binding assay, cytoprotective effect and pharmacokinetic parameters were also studied in the present work. Analytical data signified the importance of analytical tools for qualitative and quantitative analysis of glycitin in the medicine. Conclusion: Scientific data analysis revealed the therapeutic effectiveness of glycitin in the medicine.