Affiliation:
1. Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur (Rajasthan) 313001, India
Abstract
Background:
The stem bark of Ficus religiosa L. (Family-Moraceae) is traditionally
used to treat gonorrhea, diarrhea, dysentery, leucorrhea, menorrhagia, vaginal and other
urogenical disorders, ulcers and gastrohelcosis.
Objective:
The study was aimed at comparing antiulcer activity (ethanol induced gastric ulcer)
for stem bark extracts of Ficus religiosa Linn. prepared by different extraction methods
viz. soxhlet, ultrasonication and microwave assisted extraction.
Methods:
The powdered drug material was extracted by soxhlet (time 48 hours., temperature
60°C and solvent 60% ethanol), Ultrasonic (90 min., 50°C and acetone as solvent)and Microwave
(3 min., 60°C and acetone as solvent) assisted extraction method. The acute toxicity
study was carried out in adult female albino rats by “fix dose” method of OECD guideline
no. 420 for selection of doses. Antiulcerogenic effect of prepared extracts (200mg/kg) was
evaluated by ethanol induced ulcer method using omeprazole (40 mg/kg) as standard drug
and absolute alcohol 99.5% as necrotizing agent.
Result and Conclusion:
Acute toxicity study did not show any significant toxicity signs and
extracts were said to be practically non-toxic at tested dose level of 2000 mg/kg, b.w. The
best antiulcer activity was shown by the hydroalcoholic extract prepared by soxhlet extraction
method. Administration of ethanol produced significant ulcer index (41.00 ± 1.75) in the
control group. Standard drug omeprazole (40 mg/kg) produced percentage protection of
70.31%. Among all three extracts, Ulcer index is significantly (p<0.001) protected by hydroalcoholic
extract (Soxhlet Extraction Method) with percentage protection 52.02%.
Publisher
Bentham Science Publishers Ltd.
Subject
Complementary and alternative medicine,Drug Discovery
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