Paraoxonase-1: Characteristics and Role in Atherosclerosis and Carotid Artery Disease-Reference-Cited by-同舟云学术

Paraoxonase-1: Characteristics and Role in Atherosclerosis and Carotid Artery Disease

Published:2019-01-09 Issue:2 Volume:17 Page:141-146
ISSN:1570-1611
Container-title:Current Vascular Pharmacology
language:en
Short-container-title:CVP

Author:

Lioudaki S.¹,Verikokos C.²,Kouraklis G.²,Ioannou C.¹,Chatziioannou E.³,Perrea D.⁴,Klonaris C.⁵

Affiliation:

1. Vascular Department, University Hospital of Heraklion, Medical School of Crete, University of Crete, Heraklion, Greece

2. 2nd Department of Surgery, , Greece

3. Medical School of Athens, National and Kapodistrian University of Athens, Athens, Greece

4. Laboratory for Experimental Surgery and Surgical Research , Greece

5. 1st Department of Surgery, , Greece

Abstract

Paraoxonase-1 (PON-1) is a calcium-dependent enzyme that is synthesized in the liver and then secreted in blood where it is bound to high density lipoprotein (HDL). PON-1 is a hydrolase with a wide range of substrates, including lipid peroxides. It is considered responsible for many of the antiatherogenic properties of HDL. PON-1 prevents low density lipoprotein (LDL) oxidation, a process that is considered to contribute to the initiation and development of atherosclerosis. PON-1 activity and levels are influenced by gene polymorphisms; of the 2 common variants, one is in position 192 (Q192R) and one in position 55 (M55L). Also, many drugs affect PON-1 activity. The role of PON-1 in carotid atherosclerosis is inconsistent. Some studies show an association of PON-1 polymorphisms with carotid plaque formation, whereas others do not. The aim of this review is to summarize the characteristics of PON-1, its interactions with drugs and its role in atherosclerosis and especially its relationship with carotid artery disease.

Publisher

Bentham Science Publishers Ltd.

Subject

Cardiology and Cardiovascular Medicine,Pharmacology

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