Affiliation:
1. Department of Geriatrics, The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian 223002,China
Abstract
Background:
Pro-inflammatory mediators and oxidative stress are related to severity of angina pectoris in patients with coronary heart disease.
Objective:
We evaluated the effects of pro-inflammatory mediators and oxidative stress on recurrent angina pectoris after coronary artery stenting in elderly patients.
Methods:
We determined the expression levels of malondialdehyde (MDA), acrolein (ACR), tumour
necrosis factor-α (TNF-α), toll-like receptor 4 (TLR4), superoxide dismutase 3 (SOD3), paraoxonase-1
(PON-1), stromal cell-derived factor-1α (SDF-1α) and endothelial progenitor cells (EPCs) in elderly
patients with recurrent angina pectoris after coronary artery stenting.
Results:
Levels of MDA, ACR, TNF-α and TLR4 were significantly increased (p<0.001), and levels of
SOD3, PON-1, SDF-1α and EPCs were significantly decreased (p<0.001) in the elderly patients with
recurrent angina pectoris after coronary artery stenting. MDA, ACR, TNF-α and TLR4 as markers of
oxidative stress and pro-inflammatory mediators may have suppressed SOD3, PON-1, SDF-1α and
EPCs as markers of anti-oxidative stress/anti-inflammatory responses. Oxidative stress and proinflammatory
mediators were important factors involved in recurrent angina pectoris of elderly patients
after coronary artery stenting.
Conclusion:
Oxidative stress and pro-inflammatory mediators could be considered as potential noninvasive
prognostic, predictive, and therapeutic biomarkers for stable recurrent angina and recurrent
unstable angina in elderly patients after coronary artery stenting.
Publisher
Bentham Science Publishers Ltd.
Subject
Cardiology and Cardiovascular Medicine,Pharmacology
Reference70 articles.
1. Javid A.Z.; Haybar H.; Dehghan P.; The effects of Melissa officinalis (lemon balm) in chronic stable angina on serum biomarkers of oxidative stress, inflammation and lipid profile. Asia Pac J Clin Nutr 2018,27(4),785-791
2. Kumari R.; Kumar S.; Ahmad M.K.; Promoter variants of TNF-α rs1800629 and IL-10 rs1800871 are independently associated with the susceptibility of coronary artery disease in north Indian. Cytokine 2018,110,131-136
3. Rolski F.; Błyszczuk P.; Complexity of TNF-α signaling in heart disease. J Clin Med 2020,9(10),3267
4. Colmorten K.B.; Nexoe A.B.; Sorensen G.L.; The dual role of surfactant protein-D in vascular inflammation and development of cardiovascular disease. Front Immunol 2019,10,2264
5. Sawano M.; Katsuki T.; Kitai T.; Beta blockers versus calcium channel blockers for provocation of vasospastic angina after drug-eluting stent implantation: a multicentre prospective randomised trial. Open Heart 2020,7(2)
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