Ryanodine Receptors for Drugs and Insecticides: An Overview
-
Published:2018-12-06
Issue:1
Volume:19
Page:22-33
-
ISSN:1389-5575
-
Container-title:Mini-Reviews in Medicinal Chemistry
-
language:en
-
Short-container-title:MRMC
Affiliation:
1. Research Institute of Pesticidal Design & Synthesis, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi Province, China
Abstract
Ryanodine receptors (RyRs) are calcium channels located on the endo(sarco)plasmic reticulum
of muscle cells and neurons. They regulate the release of stored intracellular calcium and play a
critical role in muscle contraction. The N-terminal part of these receptors accounts for roughly 80%
and contains the binding sites for diverse RyRs modulators. The C-terminal domain contains the
transmembrane region. This review summarizes the current knowledge about the molecular biology of
insect RyRs, chemicals targeting mammal or insect RyRs, and the reasons for mammal RyR-related
diseases and diamides resistances. It may lay the foundation for effective management of mammal
RyR-related diseases and diamides resistances.
Funder
Special Funds of Central Colleges Basic Scientific Research Operating Expenses. Northwest A&F University National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Reference115 articles.
1. Sattell DB, Cordova D, Cheek TR. Invert Neurosci, Insect ryanodine receptors: molecular targets for novel pest control chemicals.,, 2008, 8,, 107-119, 2. Amador FJ, Stathopulos PB, Enomoto M, Ikura M. FEBS J, Ryanodine receptor calcium release channels: Lessons from structure-function studies.,, 2013, 280,, 5456-5470, 3. Lanner JT, Georgiou DK, Joshi AD, Hamilton SL. Perspect Biol, Ryanodine receptors: Structure, expression, molecular details, and function in calcium release. CSH.,, 2010, 2,, a003996-, 4. Jefferies PR, Blumenkopf TA, Gengo PJ, Cole LC, Casida JE. J Med Chem, Ryanodine action at calcium release channels. 1. importance of hydroxyl substituents.,, 1996, 39,, 2331-2338, 5. Lahm GP, Cordova D, Barry JD. Bioorg Med Chem, New and selective ryanodine receptor activators for insect control.,, 2009, 17,, 4127-4133,
Cited by
18 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|