Author:
Mosayebi Mahdi,Moini Latif,Hajihossein Reza,Didehdar Mojtaba,Eslamirad Zahra
Abstract
Background & Purpose:
Humans act as an intermediate host for Toxocara canis and Toxocara cati. Toxocara may be an important risk factor for asthma in humans. The aim of the present study was to evaluate immunoglobulin G (IgG) anti-Toxocara canis antibody, using enzyme-linked immunosorbent assay (ELISA) in asthmatic patients (aged 5-15 years), referring to a clinic of pulmonary diseases in Arak, Iran.
Materials & Methods:
In this bi-group cross sectional study, serum samples were collected from 110 children with confirmed asthma and 70 children without asthma within one year. IgG anti-Toxocara antibody was detected via ELISA method. The collected data were analyzed, using SPSS.
Results:
The seroprevalence of antibodies against Toxocara species was estimated at 1.8% (two males) in asmathic children via ELISA method; however, no antibodies against Toxocara canis were detected in the control group. There was no significant correlation between the frequency of antibodies against Toxocara and variables such as age, gender, or place of residence (P>0.05). Moreover, the frequency of antibodies against Toxocara was not significantly correlated with contact with dogs, consumption of unwashed fruits and vegetables, or use of raw/undercooked sheep liver (P>0.05).
Conclusion:
The present study showed anti-Toxocara antibody in 1.8% of asthmatic children and determined the seroprevalence of toxocariasis in asthmatic children and adolescents in Arak, Iran. Based on the findings, the low rate of infection with Toxocara among asthmatic children may be attributed to acceptable personal hygiene and religious considerations.
Publisher
Bentham Science Publishers Ltd.
Subject
General Immunology and Microbiology
Reference32 articles.
1. Muñoz-Guzmán MA, del Río-Navarro BE, Valdivia-Anda G, Alba-Hurtado F.
The increase in seroprevalence to Toxocara canis in asthmatic children is related to cross-reaction with Ascaris suum antigens.
Allergol Immunopathol (Madr)
2010;
38
(3)
: 115-21.
2. Magnaval JF.
GLickman LT, Dorchios P, Morassin B. Highlights human toxocariasis in school children.
Parasitol
2001;
39
: 1-12.
3. Glickman LT.
The epidemiology of human toxocariasis. In: Lewis , Maizels RM, Eds.
Toxocara and Toxocariasis: Clinical, Epidemiological and Molecular Perspectives. 1st.
London: Birbeck & Sons 1993.
4. van Ree R, Cabanes-Macheteau M, Akkerdaas J, et al.
Beta(1,2)-xylose and alpha(1,3)-fucose residues have a strong contribution in IgE binding to plant glycoallergens.
J Biol Chem
2000;
275
(15)
: 11451-8.
5. Pinelli E, Withagen C, Fonville M, et al.
Persistent airway hyper-responsiveness and inflammation in Toxocara canis-infected BALB/c mice.
Clin Exp Allergy
2005;
35
(6)
: 826-32.
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献