Affiliation:
1. Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
2. Department of Biochemistry,
Falavarjan Branch, Islamic Azad University, Isfahan, Iran
3. Razi Herbal Medicines Research Center, Lorestan
University of Medical Sciences, Khorramabad, Iran
Abstract
Background:
Candidiasis is a serious problem in women's health that is caused by Candida
species, especially Candida albicans. In this study, the effect of carotenoids in carrot extracts on
Candida species including Candida albicans ATCC1677, Candida glabrata CBS2175, Candida
parapsilosis ATCC2195, and Candida tropicalis CBS94 was investigated.
Methods:
In this descriptive study, the carrot plant was prepared from a carrot planting site in
December 2012, and then the characteristics of the plant were determined. After extracting
carotenoids from carrots, the susceptibility of different Candida species to carotenoids in carrot extract
was determined. Also, the minimum inhibitory concentration and the minimum lethal concentration of
the extracts were measured by the macro-dilution method. Finally, the data were analyzed by SPSS
software using the Kruskal-Wallis test and Mann-Whitney post-hoc test with Bonferroni adjustment.
Results:
The highest growth inhibition zone was obtained for carrot extract at a concentration of 500
mg/ml for C. glabrata and C. tropicalis. The MFC of carrot extract on Candida species was 62.5
mg/ml for C. albicans, C. glabrata, and C. parapsilosis, and 125 mg/ml for C. tropicalis. The MFC of
carrot extract on Candida species was 125 mg/ml for C. albicans, C. glabrata, and C. parapsilosis,
and 250 mg/ml for C. tropicalis.
Conclusion:
The present study can be the starting point for research activities in this direction and
promises new therapies based on the use of carotenoids.
Funder
Islamic Azad University, Falavarjan Branch, Isfahan
Publisher
Bentham Science Publishers Ltd.
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