Chemistry of 2-(Piperazin-1-yl) Quinoline-3-Carbaldehydes

Author:

Salem Mohammed A.1,Gouda Moustafa A.2,El-Bana Ghada G.3

Affiliation:

1. Department of Chemistry, Faculty of Arts and Science, Mohail Asir, King Khalid University, Rafha, Saudia Arabia | Department of Chemistry, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt

2. Department of Chemistry, Faculty of Science and Arts, Taibah University, Ulla, Medina, Saudi Arabia | Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura 35516, Egypt

3. Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura 35516, Egypt | Laboratory Department, Mansoura University Student Hospital, Mansoura University, El-Gomhoria Street, Mansoura ET- 35516, Egypt

Abstract

Abstract: This review described the preparation of 2- chloroquinoline-3-carbaldehyde derivatives 18 through Vilsmeier-Haack formylation of N-arylacetamides and the use of them as a key intermediate for the preparation of 2-(piperazin-1-yl) quinoline-3-carbaldehydes. The synthesis of the 2- (piperazin-1-yl) quinolines derivatives was explained through the following chemical reactions: acylation, sulfonylation, Claisen-Schmidt condensation, 1, 3-dipolar cycloaddition, one-pot multicomponent reactions (MCRs), reductive amination, Grignard reaction and Kabachnik-Field’s reaction.

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

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