Synthesis of pyrimido [4, 5-b] quinolones from 6-Aminopyrimidin-4-(thi)one derivatives-Reference-Cited by-同舟云学术

Synthesis of pyrimido [4, 5-b] quinolones from 6-Aminopyrimidin-4-(thi)one derivatives

Published:2022-11-04 Issue: Volume:20 Page:
ISSN:1570-193X
Container-title:Mini-Reviews in Organic Chemistry
language:en
Short-container-title:MROC

Author:

Gouda Moustafa A.¹²^ORCID,Abu-Hashem Ameen Ali³⁴^ORCID,Ameen Taha A.⁴⁵^ORCID,Salem Mohammed A.⁶⁷^ORCID

Affiliation:

1. Department of Chemistry, Faculty of Science and Arts, Taibah University, AlUla, Medina, Saudi Arabia.

2. Department of Chemistry, Faculty of Science, Mansoura University, Mansoura 35516, Egypt

3. Photochemistry Department (Heterocyclic Unit), National Research Centre, Dokki, Giza c, Egypt

4. Chemistry Departments, Faculty of Science, Jazan University, Jazan 45142, Saudi Arabia

5. Chemistry Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt

6. Department of Chemistry, Faculty of Science and Arts, King Khalid University, Saudia Arabia

7. Department of Chemistry, Department of Chemistry, 11284 Nasr City, Cairo, Egypt

Abstract

Abstract: Quinoline and pyrimidine are well-known moieties, which appear in various natural and synthetic products. Furthermore, quinoline-pyrimidine-inspired hybrids are known to have several biological properties. In addition, many pyrimido[4,5-b]quinolinone ring systems, specifically concerning medicinal chemistry, have been reported over the past decade. This review depicts the synthesis of pyrimido[4, 5-b] quinolones (PyQs4,5-b) through 6-aminopyrimidin-4-(thi)one derivatives. The preparation of PyQs4,5-b was clarified through the following chemical reactions: Vilsmeier-Haack formylation, Hantzsch-like reaction, and one-pot three-component reaction.

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

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