Affiliation:
1. Department of Chemistry Faculty of Science Taibah University Al-Madinah Al-Munawarah 30002 Saudi Arabia
2. Department of Chemistry Faculty of Science Mansoura University Mansoura 35516 Egypt
3. Department of Physical Sciences Chemistry Division College of Science Jazan University Jazan 45142 Saudi Arabia
4. Photochemistry Department (Heterocyclic Unit) National Research Centre 12622 Dokki Giza Egypt
5. Department of Chemistry Faculty of Science Albaha University P.O.Box 1988 Albaha 65799 Saudi Arabia
Abstract
AbstractQuinoline and pyrimidine moieties are ubiquitous components in both natural and synthetic compounds, showcasing diverse applications. The fusion of these well‐known structures into hybrid molecules has garnered attention due to their intriguing biological properties. Particularly in the field of medicinal chemistry, numerous studies in the last decade have focused on pyrimido[5,4‐c]quinoline ring systems (PyQs5,4‐c). This review elucidates the synthesis of PyQs5,4‐c and their derivatives using 3,4‐difunctionalized quinoline as a key starting material. The preparation of PyQs5,4‐c involves a series of chemical transformations, including the Friedländer, Ullmann and Biginelli reaction, Vilsmeier‐Haack formylation, Suzuki coupling, and a one‐pot three‐component reaction. These synthetic routes not only offer access to diverse PyQs5,4‐c derivatives