Synthesis and Biological Activity of Pyridopyridazine Derivatives: A Mini Review
-
Published:2018-11-19
Issue:1
Volume:16
Page:3-11
-
ISSN:1570-193X
-
Container-title:Mini-Reviews in Organic Chemistry
-
language:en
-
Short-container-title:MROC
Author:
Wojcicka Anna1, Nowicka-Zuchowska Anna1
Affiliation:
1. Department of Drugs Technology, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland
Abstract
This review presents most of the literature data about synthesis and biological activity of pyridopyridazine
derivatives. There are six structural isomers of the bicyclic ring system containing pyridine
moiety condensed with pyridazine nucleus. Pyridopyridazine derivatives show antitumor, antibacterial,
analgesic and diuretics activities. The derivatives have been identified as the selective phosphodiesterase
5 and phosphodiesterase 4 inhibitors. Pyridopyridazines are novel class of GABA-A receptor
benzodiazepine binding site ligands. Some of pyrido[3,2-c]pyridazine derivatives possess molluscicidal
activity and can be used as biodegradable agrochemicals. The broad spectrum of biological
activity of pyridopyridazine derivatives is the main reason for the preparation of new compounds containing
this scaffold.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry
Reference30 articles.
1. Tomita K, Tsuzuki Y, Shibamori K, Tashima M, Kajikawa F, Sato Y, Kashimoto S, Chiba K, Hino K. J Med Chem, Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 1.,, 2002, 45,, 5564-5575, 2. Kaizerman J, Lucas B, McMinn D, Zmboni R. , Pyridopyridazine
compounds, compositions and methods of use.
US0099173 A1,, , 2009 3. Kaizerman JA, Aaron W, An S, Austin R, Brown M, Chong A, Lee G. Bioorg Med Chem Lett, Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines.,, 2010, 20,, 4607-4610, 4. Bold G, Altmann KH, Frei J, Lang M, Manley PW, Traxler P, Wietfeld B, Brüggen J, Buchdunger E, Cozens R, Ferrari S, Furet P, Hofmann F, Martiny-Baron G, Mestan J, Rösel J, Sills M, Stover D, Acemoglu F, Boss E, Emmenegger R, Lässer L, Masso E, Roth R, Schlachter C, Vetterli W, Wyss D, Wood JM. J Med Chem, New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis.,, 2000, 43,, 2310-2323, 5. Kumar V, Sanna VK, Singh AT, Jaggi M, Sharma PK, Irchhaiya R, Burman AC. J Sci Islam Repub Iran, Synthesis and anti-cancer activity of pyrido[2,3-c]pyridazine derivatives.,, 2009, 20,, 325-329,
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|