Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines-Reference-Cited by-同舟云学术

Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines

Published:2010-08 Issue:15 Volume:20 Page:4607-4610
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Kaizerman Jacob A.,Aaron Wade,An Songzhu,Austin Richard,Brown Matt,Chong Angela,Huang Tom,Hungate Randall,Jiang Ben,Johnson Michael G.,Lee Gary,Lucas Brian S.,Orf Jessica,Rong Minqing,Toteva Maria M.,Wickramasinghe Dineli,Xu Guifen,Ye Qiuping,Zhong Wendy,McMinn Dustin L.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. Hedgehog signaling in animal development: paradigms and principles

2. Targeting the Hedgehog pathway in cancer

3. The Hedgehog Response Network: Sensors, Switches, and Routers

4. Basal cell carcinomas: attack of the hedgehog

5. Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade

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