Affiliation:
1. Faculty of Chemistry, Urmia University, Urmia, Iran
Abstract
Aim and Objective:
The reaction of cyclohexylisocyanide and 2-aminopyridine-3-
carboxylic acid in the presence of benzaldehyde derivatives in ethanol led to 3-(cyclohexylamino)-2-
arylimidazo[1,2-a]pyridine-8-carboxylic acids in high yields. In a three component condensation
reaction, isocyanide reacts with 2-aminopyridine-3-carboxylic acid and aromatic aldehydes without
any prior activation.
Material and Methods:
The synthesized products have stable structures which have been
characterized by IR, 1H, 13C and Mass spectroscopy as well as CHN-O analysis.
Results:
In continuation of our attempts to develop simple one-pot routes for the synthesis of 3-
(cyclohexylamino)-2-arylimidazo[1,2-a]pyridine-8-carboxylic acids, aromatic aldehydes with divers
substituted show a high performance.
Conclusion:
In conclusion, this study introduces the art of combinatorial chemistry using a simple
one-pot procedure for the synthesis of new materials which are interesting compounds in medicinal
and biological sciences.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Computer Science Applications,Drug Discovery,General Medicine
Cited by
4 articles.
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