Affiliation:
1. Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, China
2. Department of Neurology, Jilin Central General Hospital, Jilin 132011, China
Abstract
Aim and Objective:
Effective components and the mechanism of action of Zhichan powder
for the treatment of Parkinson's disease were researched at a systematic level.
Materials and Methods:
Screening of active components in Zhichan powder for the treatment of
Parkinson's disease was conducted using the Traditional Chinese Medicine Systems Pharmacology
database, and a medicine-target-disease network was established with computational network
pharmacology.
Results:
By using network pharmacology methods, we identified 18 major active components in
Zhichan powder through screening, indicating a connection between chemical components of this
Traditional Chinese Medicine and Parkinson’s disease-related targets.
Conclusion:
The medicine-target-disease system of Zhichan powder established by network
pharmacology permitted visualization of clustering and differences among chemical components in
this prescription, as well as the complex mechanism of molecular activities among those effective
components, relevant targets, pathways, and the disease. Thus, our results provide a new perspective
and method for revealing the mechanism of action of Traditional Chinese Medicine prescriptions.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Computer Science Applications,Drug Discovery,General Medicine
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