Mechanism of the Anti‐Influenza Functions of Guizhi Granules Based on Network Pharmacology, Molecular Docking, and in Vitro Experiments

Author:

Ling Wei1,Li Xiang1,Liu Xiaoyu1,Wu Qian1,Wang Weilong2,Meng Jin2,Sun Baochang2,Lv Binbin2ORCID

Affiliation:

1. Pharmacy Department Qinhuai Medical District, General Hospital of Eastern Theater Command Nanjing Jiangsu 210001 China

2. Wenzhou Center for Disease Control and Prevention Wenzhou Zhejiang 325000 China

Abstract

AbstractGuizhi granules mainly treat colds and improve overall health. They are widely used in clinical practice, but their protective effect and anti‐inflammatory mechanism against influenza are unclear. In this study, the therapeutic effect of Guizhi granules on influenza was verified in vitro. The active compounds, targets, and cellular pathways of Guizhi granules against influenza were predicted using network pharmacology. The protein‐protein interaction and component‐target networks identified 5 core targets (JUN, TNF‐α, RELA, AKT1, and MAPK1) and components (dihydrocapsaicin, kumatakenin, calycosin, licochalcone A, and berberine). GO and KEGG enrichment analyses revealed the anti‐influenza pathways of Guizhi granules as antiviral and anti‐inflammatory pathways. Molecular docking further verified that the core targets and components have good or strong binding activity. Therefore, the active ingredients, targets, and molecular mechanisms of Guizhi granules involved in influenza treatment were elucidated.

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

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