Amino Acids Regulate Glycolipid Metabolism and Alter Intestinal Microbial Composition-Reference-Cited by-同舟云学术

Amino Acids Regulate Glycolipid Metabolism and Alter Intestinal Microbial Composition

Published:2020-11-09 Issue:8 Volume:21 Page:761-765
ISSN:1389-2037
Container-title:Current Protein & Peptide Science
language:en
Short-container-title:CPPS

Author:

Xie Fei¹,Liu Zhengqun¹,Liu Ming¹,Chen Liang¹,Ding Wei²,Zhang Hongfu¹

Affiliation:

1. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

2. Department of Gerontology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China

Abstract

Amino acids (AAs) and their metabolites regulate key metabolic pathways that are necessary for growth, reproduction, immunity and metabolism of the body. It has been convinced that metabolic diseases are closely related to disorders of glycolipid metabolism. A growing number of studies have shown that AAs are closely related to energy metabolism. This review focuses on the effects of amino acids (arginine, branched-chain amino acids, glutamine) and their metabolites (short chain fatty acids) on glycolipid metabolism by regulating PI3K/AKT/mTOR and AMPK signaling pathways and GPCRs receptors, reducing intestinal Firmicutes/Bacteroidetes ratio associated with obesity.

Funder

Agriculture Science and Technology Innovation Program

CAAS

National Natural Science Foundation of China

Publisher

Bentham Science Publishers Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,General Medicine

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