Affiliation:
1. Shandong University of Traditional Chinese Medicine, Jinan, 250000, China
Abstract
Diabetes mellitus (DM) has become an increasingly common disease with high disability and
mortality rates. Diabetes complications are the main cause of diabetes death and about 50% of diabetic
patients died from heart disease in developed countries reported by World Health Organization. Diabetic
cardiomyopathy (DCM) has been considered as a high incidence and serious complication of DM and
plays a key role in the incidence and development of diabetes related heart failure. Metabolism dysregulation
is regarded as an important and earlier factor occurred in the pathogenesis of DCM. Insulin resistance,
oxidative stress, inflammation and mitochondrial dysfunction also contribute to the development
of DCM. Farnesoid X Receptor (FXR) is a member of nuclear receptor superfamily, and plays a critical
role in regulating lipid and glucose metabolism, oxidative stress and inflammation. FXR is activated by
primary bile acids (BAs) such as chenodeoxycholic acid, cholic acid and synthetic agonists such as
obeticholic acid. BAs are the main active ingredients of many natural products and traditional medicines,
especially bile or gallstones in animals, such as calculus bovis. Due to the regulatory effect of
FXR on glucose and lipid metabolism, oxidative stress and inflammation, the treatment of BAs and FXR
agonists for metabolic syndrome and DCM have gained more attention. This review will focus on the
pathogenesis of diabetic cardiomyopathy and the regulatory effect of BAs and FXR on DCM.
Funder
National Nature Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Cell Biology,Molecular Biology,Biochemistry,General Medicine
Cited by
12 articles.
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