FTO in Lung Cancer: Its Progression and Therapeutic Potential-Reference-Cited by-同舟云学术

FTO in Lung Cancer: Its Progression and Therapeutic Potential

Published:2024-09 Issue:15 Volume:27 Page:2301-2307
ISSN:1386-2073
Container-title:Combinatorial Chemistry & High Throughput Screening
language:en
Short-container-title:CCHTS

Author:

Chen Xue-Fen¹,Gong Chen¹

Affiliation:

1. Geriatrics Respiratory Medicine Department, First Affiliated Hospital of Guangxi Medical University, Nanning, China

Abstract

Abstract: One of the most fatal and frequent malignancies on the planet is lung cancer. Its occurrence and development are the results of multifactorial and multigenic interactions. In recent years, RNA N6-methyladenosine transferase (FTO) has gained significant attention in the field of oncology. FTO is the first RNA demethylase to be found to control target mRNA demethylation. The growth, proliferation, and metastasis of tumor cells are greatly influenced by FTO. Recent studies have found that imbalanced m6A methylation regulatory proteins can induce disruption of downstream RNA metabolism, strongly affecting tumor development. This paper provides an overview of the relationship between FTO and lung cancer, discussing the mechanisms by which FTO is involved in lung cancer and its potential clinical applications.

Funder

Health Commission of Guangxi Zhuang Autonomous Region

Publisher

Bentham Science Publishers Ltd.

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