Evaluation of hs-CRP and sLOX-1 Levels in Moderate-to-High Risk Acute Coronary Syndromes-Reference-Cited by-同舟云学术

Evaluation of hs-CRP and sLOX-1 Levels in Moderate-to-High Risk Acute Coronary Syndromes

Published:2020-01-07 Issue:1 Volume:20 Page:96-103
ISSN:1871-5303
Container-title:Endocrine, Metabolic & Immune Disorders - Drug Targets
language:en
Short-container-title:EMIDDT

Author:

Çoner Ali¹,Aydınalp Alp²,Müderrisoğlu Haldun²

Affiliation:

1. Department of Cardiology, Başkent University Hospital Alanya Application and Research Center, Alanya/Antalya, Turkey

2. Department of Cardiology, Başkent University Faculty of Medicine, Ankara, Turkey

Abstract

Objective: Risk stratification and prompt treatment are essential for the management of acute coronary syndromes (ACS) and prediction of future prognosis. Subclinical vascular inflammation and novel biomarkers play an important role in the clinical evaluation of ACS patients. Methods: We enrolled patients who were admitted to emergency service with unstable angina or non- ST segment elevated ACS (NSTE-ACS) in the study population. Coronary artery disease (CAD) complexity was determined via evaluation of angiographical views and peripheral venous blood samples were collected to measure highly sensitive C-reactive protein (hs-CRP) and soluble form of Lectin-like OxLDL receptor-1 (sLOX-1) levels. Results: A total of 40 patients were enrolled in the study population, mean age was 65.1±13.8 years and male gender percentage was 52.5%. Twenty-nine of patients had NSTE-ACS and 11 patients had unstable angina presentation. The modified Gensini scores were higher for patients with elevated hs- CRP and sLOX-1 levels. Conclusion: Vascular inflammation displays the onset of ACS and it is related to more complex CAD in these patients. An increase in sLOX-1 expression is closely related to anatomical complexity of CAD in ACS..

Funder

Ba?kent University

Publisher

Bentham Science Publishers Ltd.

Subject

Immunology and Allergy,Endocrinology, Diabetes and Metabolism

Reference41 articles.

1. Gaziano T.A.; Prabhakaran D.; Gaziano J.M.; Global Burden of Cardiovascular Disease.Braunwald’s Heart Disease, A Textbook of Cardiovascular Medicine 2015,Vol. 10,1-20

2. Lozano R.; Naghavi M.; Foreman K.; Lim S.; Shibuya K.; Aboyans V.; Abraham J.; Adair T.; Aggarwal R.; Ahn S.Y.; Alvarado M.; Anderson H.R.; Anderson L.M.; Andrews K.G.; Atkinson C.; Baddour L.M.; Barker-Collo S.; Bartels D.H.; Bell M.L.; Benjamin E.J.; Bennett D.; Bhalla K.; Bikbov B.; Bin Abdulhak A.; Birbeck G.; Blyth F.; Bolliger I.; Boufous S.; Bucello C.; Burch M.; Burney P.; Carapetis J.; Chen H.; Chou D.; Chugh S.S.; Coffeng L.E.; Colan S.D.; Colquhoun S.; Colson K.E.; Condon J.; Connor M.D.; Cooper L.T.; Corriere M.; Cortinovis M.; de Vaccaro K.C.; Couser W.; Cowie B.C.; Criqui M.H.; Cross M.; Dabhadkar K.C.; Dahodwala N.; De Leo D.; Degenhardt L.; Delossantos A.; Denenberg J.; Des Jarlais D.C.; Dharmaratne S.D.; Dorsey E.R.; Driscoll T.; Duber H.; Ebel B.; Erwin P.J.; Espindola P.; Ezzati M.; Feigin V.; Flaxman A.D.; Forouzanfar M.H.; Fowkes F.G.; Franklin R.; Fransen M.; Freeman M.K.; Gabriel S.E.; Gakidou E.; Gaspari F.; Gillum R.F.; Gonzalez-Medina D.; Halasa Y.A.; Haring D.; Harrison J.E.; Havmoeller R.; Hay R.J.; Hoen B.; Hotez P.J.; Hoy D.; Jacobsen K.H.; James S.L.; Jasrasaria R.; Jayaraman S.; Johns N.; Karthikeyan G.; Kassebaum N.; Keren A.; Khoo J.P.; Knowlton L.M.; Kobusingye O.; Koranteng A.; Krishnamurthi R.; Lipnick M.; Lipshultz S.E.; Ohno S.L.; Mabweijano J.; MacIntyre M.F.; Mallinger L.; March L.; Marks G.B.; Marks R.; Matsumori A.; Matzopoulos R.; Mayosi B.M.; McAnulty J.H.; McDermott M.M.; McGrath J.; Mensah G.A.; Merriman T.R.; Michaud C.; Miller M.; Miller T.R.; Mock C.; Mocumbi A.O.; Mokdad A.A.; Moran A.; Mulholland K.; Nair M.N.; Naldi L.; Narayan K.M.; Nasseri K.; Norman P.; O’Donnell M.; Omer S.B.; Ortblad K.; Osborne R.; Ozgediz D.; Pahari B.; Pandian J.D.; Rivero A.P.; Padilla R.P.; Perez-Ruiz F.; Perico N.; Phillips D.; Pierce K.; Pope C.A.; Porrini E.; Pourmalek F.; Raju M.; Ranganathan D.; Rehm J.T.; Rein D.B.; Remuzzi G.; Rivara F.P.; Roberts T.; De León F.R.; Rosenfeld L.C.; Rushton L.; Sacco R.L.; Salomon J.A.; Sampson U.; Sanman E.; Schwebel D.C.; Segui-Gomez M.; Shepard D.S.; Singh D.; Singleton J.; Sliwa K.; Smith E.; Steer A.; Taylor J.A.; Thomas B.; Tleyjeh I.M.; Towbin J.A.; Truelsen T.; Undurraga E.A.; Venketasubramanian N.; Vijayakumar L.; Vos T.; Wagner G.R.; Wang M.; Wang W.; Watt K.; Weinstock M.A.; Weintraub R.; Wilkinson J.D.; Woolf A.D.; Wulf S.; Yeh P.H.; Yip P.; Zabetian A.; Zheng Z.J.; Lopez A.D.; Murray C.J.; AlMazroa M.A.; Memish Z.A.; Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012,380(9859),2095-2128

3. Zamani P.; Schwartz G.G.; Olsson A.G.; Rifai N.; Bao W.; Libby P.; Ganz P.; Kinlay S.; Inflammatory biomarkers, death, and recurrent nonfatal coronary events after an acute coronary syndrome in the MIRACL study. J Am Heart Assoc 2013,2(1)

4. Greco T.P.; Conti-Kelly A.M.; Anthony J.R.; Greco T.; Doyle R.; Boisen M.; Kojima K.; Matsuura E.; Lopez L.R.; Oxidized-LDL/beta(2)-glycoprotein I complexes are associated with disease severity and increased risk for adverse outcomes in patients with acute coronary syndromes. Am J Clin Pathol 2010,133(5),737-743

5. Acet H.; Ertaş F.; Bilik M.Z.; Aydın M.; Yüksel M.; Polat N.; Yıldız A.; Özyurtlu F.; Akıl M.A.; Çiftçi L.; Özbek M.; Alan S.; Toprak N.; The relationship of TIMI risk index with SYNTAX and Gensini risk scores in predicting the extent and severity of coronary artery disease in patients with STEMI undergoing primary percutaneous coronary intervention. Ther Adv Cardiovasc Dis 2015,9(5),257-266

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