Insulin Resistance and Diabetes Mellitus in Patients with Systemic Lupus Erythematosus-Reference-Cited by-同舟云学术

Insulin Resistance and Diabetes Mellitus in Patients with Systemic Lupus Erythematosus

Published:2023-04 Issue:4 Volume:23 Page:503-514
ISSN:1871-5303
Container-title:Endocrine, Metabolic & Immune Disorders - Drug Targets
language:en
Short-container-title:EMIDDT

Author:

García-Carrasco Mario¹^ORCID,Mendoza-Pinto Claudia¹²^ORCID,Munguía-Realpozo Pamela¹^ORCID,Etchegaray-Morales Ivet¹^ORCID,Vélez-Pelcastre Sandra Karina¹^ORCID,Méndez-Martínez Socorro³^ORCID,Zamora-Ginez Irma⁴^ORCID,de Lara Luis Guillermo Vázquez⁵^ORCID,Gálvez-Romero José Luis⁶^ORCID,Escamilla-Márquez Marco⁷^ORCID

Affiliation:

1. Department of Rheumatology, Medicine School, Meritorious Autonomous University of Puebla, Puebla, Mexico

2. Systemic Autoimmune Diseases Research Unit, Specialties Hospital UMAE, Mexican Social Security Institute, Puebla, Mexico

3. Research in Health Coordination, Mexican Social Security Institute, Puebla, Mexico

4. Coordination of the Master’s degree in Medical Sciences and Research, Medicine School, Meritorious Autonomous University of Puebla, Puebla, México

5. Laboratory of Experimental Medicine, Medicine School, Meritorious Autonomous University of Puebla, Puebla, Mexico

6. Research Department, Hospital Regional, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Puebla, Mexico

7. Department of Endocrinology, Medicine School, Meritorious Autonomous University of Puebla, Puebla, Mexico

Abstract

Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by damage to multiple systems and a higher risk of cardiovascular disease. In addition, several studies have found that insulin resistance (IR) is more prevalent in SLE patients than controls, increasing the risk of prediabetes, type 2 diabetes mellitus (T2DM) and morbidity. The objective of this review was to summarize the most relevant evidence about the relationship among IR, T2DM and SLE, including the effects of pro-inflammatory states, acute-phase proteins, pro-inflammatory cytokines, and pharmacological SLE treatment. A better understanding of the mechanisms involved in these comorbidities will allow better treatment strategies.

Publisher

Bentham Science Publishers Ltd.

Subject

Immunology and Allergy,Endocrinology, Diabetes and Metabolism

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