Biomarkers in Systemic Lupus Erythematosus along with Metabolic Syndrome-Reference-Cited by-同舟云学术

Biomarkers in Systemic Lupus Erythematosus along with Metabolic Syndrome

Published:2024-03-29 Issue:7 Volume:13 Page:1988
ISSN:2077-0383
Container-title:Journal of Clinical Medicine
language:en
Short-container-title:JCM

Author:

Corona-Meraz Fernanda Isadora¹²^ORCID,Vázquez-Del Mercado Mónica²³⁴^ORCID,Sandoval-García Flavio²⁴,Robles-De Anda Jesus-Aureliano²,Tovar-Cuevas Alvaro-Jovanny¹^ORCID,Rosales-Gómez Roberto-Carlos¹,Guzmán-Ornelas Milton-Omar¹^ORCID,González-Inostroz Daniel²,Peña-Nava Miguel²,Martín-Márquez Beatriz-Teresita²⁴^ORCID

Affiliation:

1. Multidisciplinary Health Research Center, Department of Biomedical Sciences, University Center of Tonala, University of Guadalajara, Guadalajara 45425, Jalisco, Mexico

2. Department of Molecular Biology and Genomics, Institute of Rheumatology and Musculoskeletal System Research, University Center of Health Sciences, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico

3. Rheumatology Service, Internal Medicine Division, Civil Hospital of Guadalajara “Dr. Juan I. Menchaca”, Guadalajara 44340, Jalisco, Mexico

4. Academic Group UDG-CA-703, “Immunology and Rheumatology”, University Center of Health Sciences, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico

Abstract

Metabolic syndrome (MetS) is a group of physiological abnormalities characterized by obesity, insulin resistance (IR), and hypertriglyceridemia, which carry the risk of developing cardiovascular disease (CVD) and type 2 diabetes (T2D). Immune and metabolic alterations have been observed in MetS and are associated with autoimmune development. Systemic lupus erythematosus (SLE) is an autoimmune disease caused by a complex interaction of environmental, hormonal, and genetic factors and hyperactivation of immune cells. Patients with SLE have a high prevalence of MetS, in which elevated CVD is observed. Among the efforts of multidisciplinary healthcare teams to make an early diagnosis, a wide variety of factors have been considered and associated with the generation of biomarkers. This review aimed to elucidate some primary biomarkers and propose a set of assessments to improve the projection of the diagnosis and evolution of patients. These biomarkers include metabolic profiles, cytokines, cardiovascular tests, and microRNAs (miRs), which have been observed to be dysregulated in these patients and associated with outcomes.

Publisher

MDPI AG

Link

https://www.mdpi.com/2077-0383/13/7/1988/pdf

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