Affiliation:
1. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2. Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
3. Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran
4. Healthy Ageing Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran
Abstract
Aims:
The purpose of this research was to investigate the effect of chrysin on one of the
natural antioxidants on aging progression in an animal model.
Background:
Oxidative stress and inflammation increase in hepatic tissue during aging, leading to
liver dysfunction.
Objective:
The current research was conducted to show the effect of chrysin on the activities of antioxidant enzyme (catalase, glutathione peroxidase, and superoxide dismutase), serum nitric oxide (NO),
and lipid peroxidation as well as inflammatory cytokines (TNF-α, IL-6, and IL-1β) of aging rats.
Method:
Male Wistar rats of different ages, 2, 10, and 20 months, were randomly divided into six
groups as follows (n=8, per each group): young control rats (C2), young CH-treated rats (CH2), middle-aged control rats (C10), middle-aged CH-treated group (CH10), aged control group (C20), and
aged CH-treated group (CH20). Chrysin (20 mg/kg) was administered intraperitoneally once a day for
30 days.
Result:
Present findings indicated that chrysin treatment ameliorated the increased liver levels of lipid
peroxidation, TNF-α, and IL-1β as well as serum levels of NO.
Conclusion:
The findings suggest that chrysin could be effective against the progression of ageinduced damage by modulation of oxidant-antioxidant system and inflammatory response.
Funder
National Institute for Medical Research Development
Publisher
Bentham Science Publishers Ltd.
Subject
Immunology and Allergy,Endocrinology, Diabetes and Metabolism
Cited by
5 articles.
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