Author:
PANDEY PANKAJ KUMAR, ,PARASHAR ASHISH KUMAR,
Abstract
This work aimed to prepare and evaluate the topical liposomal hydrogel to treat antibiotic-resistant propionic bacterium acne. Nadifloxacin-loaded liposomes were prepared by thin-film hydration technique. Nadifloxacin, soya lecithin, cholesterol were dissolved in a mixture of chloroform and taken in different levels, and liposomes were prepared. The prepared liposomes were evaluated for in-vitro drug release. Formulation F2 was the highest percentage entrapment of 71±1.50% and released 58.12±1.2% of the drug in 6hrs. Minocycline hydrochloride-based hydrogel was prepared using the methylcellulose gelling agent, and the drug concentration was kept constant at 0.25%. The concentration of propylene glycol and methylparaben was kept constant at 15% and 0.3%. The hydrogel formulation was evaluated for various physicochemical parameters like percentage drug content, spreadability, and drug release. Formulation H9 was the highest drug content, 98.23 ± 0.031%, and the drug released 90.96±2.6% of the drug in 6hr. Out of these formulations, F2 from liposomes and H9 from hydrogel formula was selected to prepare the final liposomal hydrogel formulation. Developed liposomal hydrogel(F2H9) were evaluated like size, drug content and drug entrapment spreadability, homogeneity, washability, pH, etc. In-vitro drug release from liposomal hydrogel in Nadifloxacin release 54.86±3.1% and Minocycline hydrochloride 91.24±1.82% in 6hr. Developed liposomal hydrogel formulation can better treat acne due to high drug retention and permeation in skin layers. KEYWORDS: Acne, antibiotics, liposomes, hydrogel, Nadifloxacin, Minocycline hydrochloride
Publisher
Current Research in Pharmaceutical Sciences
Subject
General Materials Science
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Formulation and Evaluation of Multipurpose Herbal Cream;International Journal of Newgen Research in Pharmacy & Healthcare;2024-06-30
2. Enhancement of Repaglinide Dissolving Rate by the Application of the Solid Dispersion Method;International Journal of Newgen Research in Pharmacy & Healthcare;2024-06-30
3. Design and Development of Topical Hydrogel of <i>Centella Asiatica</i> for the Treatment of Skin Burn;International Journal of Newgen Research in Pharmacy & Healthcare;2024-06-30
4. Exploring Skin Anti-Aging Strategies: An Overview;International Journal of Newgen Research in Pharmacy & Healthcare;2024-06-30