Enhancement of Repaglinide Dissolving Rate by the Application of the Solid Dispersion Method

Abstract

The recent work primarily set out to evaluate and synthesize the Repaglinide (RG) solid dispersion. The medicine rifampicin is classified as a class II biopharmaceutical due to its low water solubility. Through the use of solvent evaporation and a range of PVP K30 ratios, a Repaglinide solid dispersion (RG-SD) was produced. A battery of tests, including in vitro dissolution testing, drug content analysis, X-ray diffraction (XRD), and differential scanning calorimetry (DSC), were performed on the produced RG-SD. Research using Differential Scanning Calorimetry (DSC) and X-ray Diffraction (XRD) has shown that the solid dispersion of the examined material, RG, is amorphous. Purified RG's solubility in distilled water was enhanced from 34.41±0.68 to 370.3±1.52 μg/mL when the temperature was maintained at 37°C. Within the first half an hour, the RG-SD (RG:PVP K30) (1:10) formulation showed a notable surge release of 65%. A recent scientific study found that Repaglinide's characteristics were improved when PVP-K30 (1:10) was used as a carrier in solid dispersions of the drug.