Association Between the Development of Thrombosis and Worsening of Disease Severity in Patients With Moderate COVID-19 on Admission ― From the CLOT-COVID Study ―

Author:

Ikeda Satoshi1,Ueno Yuki1,Maemura Koji1,Yachi Sen2,Takeyama Makoto2,Nishimoto Yuji3,Tsujino Ichizo4,Nakamura Junichi4,Yamamoto Naoto5,Nakata Hiroko6,Umetsu Michihisa7,Aikawa Shizu8,Hayashi Hiroya9,Satokawa Hirono10,Okuno Yoshinori11,Iwata Eriko12,Ogihara Yoshito13,Ikeda Nobutaka14,Kondo Akane15,Iwai Takehisa16,Yamada Norikazu17,Ogawa Tomohiro18,Kobayashi Takao5,Mo Makoto19,Yamashita Yugo11,

Affiliation:

1. Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences

2. Japan Community Health Care Organization Tokyo Shinjuku Medical Center

3. Hyogo Prefectural Amagasaki General Medical Center

4. Hokkaido University Hospital

5. Hamamatsu Medical Center

6. Yokosuka General Hospital Uwamachi

7. Tohoku University Hospital

8. Tsukuba Medical Center Hospital

9. Osaka City University Graduate School of Medicine

10. Fukushima Medical University, School of Medicine

11. Kyoto University Hospital

12. Nankai Medical Center Japan Community Health Care Organization

13. Mie University Hospital

14. Toho University Ohashi Medical Center

15. Shikoku Medical Center for Children and Adults

16. Tsukuba Vascular Center

17. Kuwana City Medical Center

18. Fukushima Daiichi Hospital

19. Yokohama Minami Kyosai Hospital

Publisher

Japanese Circulation Society

Subject

Cardiology and Cardiovascular Medicine,General Medicine

Reference39 articles.

1. 1. Umeh C, Tuscher L, Ranchithan S, Watanabe K, Gupta R. Predictors of COVID-19 mortality in critically ill ICU patients: A multicenter retrospective observational study. Cureus 2022; 14: e20952. doi:10.7759/cureus.20952.

2. 2. Reyes LF, Murthy S, Garcia-Gallo E, Irvine M, Merson L, Martin-Loeches I, et al. Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: A prospective, multinational, multicentre, observational study. ERJ Open Res 2022; 8: 00552–2021. doi:10.1183/23120541.00552-2021.

3. 3. Gopalan N, Senthil S, Prabakar NL, Senguttuvan T, Bhaskar A, Jagannathan M, et al. Predictors of mortality among hospitalized COVID-19 patients and risk score formulation for prioritizing tertiary care: An experience from South India. PLoS One 2022; 17: e0263471. doi:10.1371/journal.pone.0263471.

4. 4. Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA 2020; 323: 2052–2059.

5. 5. Sholzberg M, Tang GH, Rahhal H, AlHamzah M, Kreuziger LB, Áinle FN, et al. Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial. BMJ 2021; 375: n2400. doi:10.1136/bmj.n2400.

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