Review of non‐monotonic dose‐responses of substances for human risk assessment

Author:

Beausoleil C.1,Beronius A.2,Bodin L.1,Bokkers B.G.H.3,Boon P.E.3,Burger M.4,Cao Y.2,De Wit L.3,Fischer A.4,Hanberg A.2,Leander K.2,Litens‐Karlsson S.2,Rousselle C.1,Slob W.3,Varret C.1,Wolterink G.3,Zilliacus J.2

Affiliation:

1. French Agency for Food, Environment and Occupational Health & Safety (ANSES)

2. Institute of Environmental Medicine, Karolinska Institutet (IMM)

3. National Institute for Public Health and the Environment (RIVM)

4. Austrian Agency for Health and Food Safety GmhH (AGES)

Publisher

Wiley

Reference39 articles.

1. AGES , 2013‐ Austrian Agency for Health & Food Safety, Institute for Plant Protection Products. «External scientific report. Case studies for the application of the Guidance of EFSA on Submission of scientific peer‐reviewed open literature for the approval of pesticide active substances under Regulation (EC) No 1107/2009, using substances for which dossiers are submitted under Regulation (EU) No 1141/20101." Report and appendixes available on the internet (http://www.efsa.europa.eu/en/supporting/doc/511e.pdf).

2. A dose‐response study following in utero and lactational exposure to di‐(2‐ethylhexyl)‐phthalate (DEHP): non‐monotonic dose‐response and low dose effects on rat brain aromatase activity;Andrade;Toxicology,2006

3. Myricetin and quercetin are naturally occurring co‐substrates of cyclooxygenases in vivo;Bai;Prostaglandins Leukotrienes & Essential Fatty Acids,2010

4. Low dose effects and non‐monotonic dose‐responses for endocrine active chemicals: Science to practice workshop: Workshop summary;Beausoleil;Chemosphere,2013

5. Environmental Chemicals: Evaluating Low‐Dose Effects;Birnbaum;Environmental health perspectives,2012

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