Affiliation:
1. National Medical and Surgical Center named after N. I. Pirogov
2. Kazan State Medical University
3. Institute of Fundamental Medicine and Biology of Kazan (Volga Region) Federal University
4. Bashkirian State Medical University
Abstract
Object. SARS-CoV-2 is a coronavirus that causes the acute respiratory infection novel coronavirus infection (COVID-19). Cells expressing ACE 2 (angiotensin converting enzyme 2) receptors, which are present in many organs and tissues of humans, including the epithelium of the nose and mouth, are susceptible to SARS-CoV-2. At the same time, hyperinflammation is characteristic of novel coronavirus infection (COVID-19), with a massive production of cytokines — the so-called cytokine storm [1]. Periodontal tissues are also highly sensitive to such hyperinflammatory reactions, which makes it possible to initiate an exacerbation of chronic periodontal pathology.
Objective: To determine the relationship between SARS-CoV-2 oral reproduction and exacerbation of chronic periodontal disease in patients with novel coronavirus infection (COVID-19).
Material and methods. Study of 18 patients of the COVID-hospital (Kazan), who are undergoing hospital treatment with a diagnosis of novel coronavirus infection (COVID-19)/community-acquired pneumonia, was carried out. To test SARS-CoV-2, material was sampled with special sterile swabs and pins from the nasopharynx, periodontal pocket and tongue surface (respectively). The method of polymerase chain reaction with reverse transcription (RT-PCR) was used.
Results. SARS-CoV-2 RNA was not detected in biomaterials from the nasopharynx, periodontal pocket and tongue surface 94.4% of patients with confirmed with new coronavirus infection (COVID-19) during acute inflammation (community-acquired pneumonia). At the same time, clinical examination showed that exacerbation of chronic generalized periodontitis was diagnosed in 100% of patients.
Conclusion. It is most likely that the exacerbation of chronic generalized periodontitis in patients with novel coronavirus infection (COVID-19) is not associated with the reproduction of SARS-CoV-2 in the oral cavity, but is a consequence of hyperactivation of immune and inflammatory defense mechanisms.
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3 articles.
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