Analysis of the mechanisms of synergistic effect in the combined use of physiotherapy factors-Reference-Cited by-同舟云学术

Analysis of the mechanisms of synergistic effect in the combined use of physiotherapy factors

Published:2021-12-04 Issue:6 Volume: Page:70-79
ISSN:2074-9961
Container-title:Fizioterapevt (Physiotherapist)
language:ru
Short-container-title:

Author:

Benkov A. A.¹^ORCID,Nagornev S. N.²^ORCID,Frolkov V. K.²^ORCID,Gusakova E. V.³^ORCID,Nagorneva M. S.⁴^ORCID

Affiliation:

1. Scientific and Organizational Department, OOO (LLC) «Med TeKo», Moscow, Russia

2. FSBI Center for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency of the Russian Federation, Moscow, Russia

3. Department of Restorative Medicine and Medical Rehabilitation with courses in Pediatrics, Nursing, Clinical Psychology and Pedagogy, FSBI FPE Central State Medical Academy of the Administrative Department of the President of the Russian Federation, Moscow, Russia

4. FSAEI HE Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University), Moscow, Russia

Abstract

The study is devoted to the analysis of the internal mechanisms of the realization of biological effects of the combined use of a low-frequency alternating electrostatic field and transcranial magnetic stimulation with a running magnetic field in patients with metabolic syndrome. The results obtained allow concluding that the simultaneous course effect of these physiotherapeutic factors is accompanied by the development of a synergistic effect, objectively assessed by a set of parameters characterizing the state of the microcirculatory-tissue system, metabolic processes and peroxide metabolism. The quantitative assessment carried out using the synergy factor allowed classifying the type of interaction of physical factors as potentiation. The analysis of the internal mechanisms of supraadditive interaction made it possible to establish that this phenomenon can be most accurately explained from the standpoint of epigenetic regulation, which is a change in gene expression with the preservation of the DNA sequence and which determines the phenomenon of functional cumulation during the course of physiotherapeutic factors. The epigenetic model of the realization of synergy acts as a molecular evidence base for the sanogenetic effects observed in patients with metabolic syndrome under the systemotropic effect of physiotherapeutic factors.

Publisher

PANORAMA Publishing House

Reference28 articles.

1. Ulashchik V.S. Sochetannaia fizioterapiia: obshchie svedeniia, vzaimodeistvie fizicheskikh faktorov [Combined physiotherapy: gen¬eral information, interaction of physical factors] // Voprosy kurortologii, fizioterapii i lechebnoi fizicheskoi kultury [Questions of balneology, physiotherapy and physical therapy]. 2016; 6: 4–11. (In Russ.)

2. Orekhova E.M., Kulchitskaia D.B., Konchugova T.V., Lukianova T.V. et al. Rol sochetannoi fizioterapii v ozdorovitelnykh i profilaktich¬eskikh programmakh [The role of combined physiotherapy in health-improving and preventive programs] // Fizioterapevt [Physiothera¬pist]. 2015; 6: 63–71. (In Russ.)

3. Benkov A.A., Nagornev S.N., Frolkov V.K., Gusakova E.V., Nagorneva M.S. Effekty odnokratnogo simultannogo vozdeistviia fizioter-apevticheskikh faktorov na stress-realizuiushchie i stress-limitiruiushchie sistemy organizma [Effects of a single simultaneous effect of physiotherapeutic factors on stress-realizing and stress-limiting systems of the body] // Fizioterapevt [Physiotherapist]. 2021; 3: 22–32. DOI 10.33920/med-14-2106-03. (In Russ.)

4. Nagornev S.N., Frolkov V.K., Kulish A.V., Puzyreva G.A., Samsonova O.S. Sistemnyi podkhod i algoritmizatsiia primeneniia transkra¬nialnykh magnitnykh vozdeistvii pri provedenii meditsinskoi reabilitatsii bolnykh s gemotsirkuliatornymi i dismetabolicheskimi narusheni¬iami [A systematic approach and algorithmization of the use of transcranial magnetic influences during medical rehabilitation of patients with hemocirculatory and dysmetabolic disorders] // Sistemnyi analiz i upravlenie v biomeditsinskikh sistemakh [Systems analysis and management in biomedical systems]. 2016; 15 (4): 651–657. (In Russ.)

5. Kulikov A.G., Iarustovskaia O.V., Kuzovleva E.V, Zaitseva T.N., Kulchitskaia D.B., Konchugova T.V. Primenenie nizkochastotnogo el-ektrostaticheskogo polia v klinicheskoi praktike [The use of a low-frequency electrostatic field in clinical practice]: manual. M.: SBEI FPE RMAPO; 2015: 44. (In Russ.)

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