The impact of harmful industrial factors on the reproductive health of workers in chemical production

Abstract

In order to solve the demographic problems of the Russian Federation, the urgent task is to develop medical and preventive technologies for managing the reproductive health risks of chemical workers, and to reduce the risk of male and female infertility. 82 workers of chemical industries were examined. The indicators of specific hormonal status, immunological, genetic, parameters of functional studies, including the reproductive system, were studied. Class of working conditions by chemical factor 3.1 («harmful» with degree of harmfulness 1). In the structure of somatic diseases in women, endocrine pathology predominated (60 % of women in the observation group and 24 % of the comparison group), in men), inflammatory diseases of the genitourinary system (41.1 % and 46.6 %, respectively). Gynecological pathology in workers exposed to harmful chemicals was found 2 times more often than in the comparison group. Workers in the observation group revealed polymorphism of genes responsible for reproductive function. When exposed to a chemical factor, immunological disorders are formed in the form of a decrease in activation markers CD95 +, CD25 + (p < 0.05); disorders of neuroendocrine regulation, hormonal dysfunction (decreased FSH in women and decreased testosterone, antisperm antibodies in men); increased content of tumor markers (CA-125 and CA-153); functional changes in the thyroid gland, structural changes in blood vessels, impaired reproductive function. Thus, exposure to production chemical factors of even low intensity contributes to the formation of hormonal and endocrine disorders, is an additional risk factor for miscarriage and the development of secondary infertility.