Effects of iron accumulation in the basal ganglia on the function of the gray matter of the brain in Parkinson’s disease

Abstract

Our goal was to assess the effect of iron accumulation in the basal ganglia on the functionality of the structures of the gray matter of the brain at stages II and III of PD using the combined use of the SWI and DTI. We examined 91 patients with PD with stages II (n = 40) and III (n = 51) according to Hoehn/Yahr scale. The patients underwent a brain scan using a Magnetom TrioATim 3.0 Tesla MRI scanner (SIEMENS, Germany), using the SWI and DTI protocols. Areas of interest on both sides: SN, RN, GP, head of the CN, PUT and ND of the cerebellum. The quantitative determination of the degree of iron deposition was carried out using the SPIN (signal processing in NMR) Software. The level of FA was assessed in the cerebral cortex and subcortical nuclei. Quantitative variables were obtained using the AAL2 atlas in the DSI Studio software environment. Statistical processing was carried out in the Statistica 12 environment (StatSoft, USA). To determine the correlations, the Spearman criterion was used. The most significant areas of the cortex that showed a greater number of correlations with the structures of the extrapyramidal system in patients with stage II PD were the left middle frontal gyrus, the left middle occipital gyrus, and the right inferior temporal gyrus. Stage III PD was characterized by more multidirectional correlations between iron deposition in the basal ganglia and the level of FA in the gray matter of the brain. It has been established that the accumulation of iron in the basal ganglia is important in the progression of the disease, which confirms the thesis about the role of ferroptosis in the genesis of neurodegenerative diseases. Thus, the combined use of SWI and DTI expands the possibilities of studying the pathogenesis of PD. English version of the article is available under title 'Influence of iron accumulation in the basal ganglia on the function of the grey matter of the brain in Parkinson's disease' at URL: https://panor.ru/articles/influence-of-iron-accumulation-in-the-basal-ganglia-on-the-function-of-the-grey-matter-of-the-brain-in-parkinsons-disease/78640.html