Arterial carbon dioxide and bicarbonate rather than pH regulate cerebral blood flow in the setting of acute experimental metabolic alkalosis

Author:

Caldwell Hannah G.1ORCID,Howe Connor A.1ORCID,Chalifoux Carter J.1ORCID,Hoiland Ryan L.23ORCID,Carr Jay M. J. R.1ORCID,Brown Courtney V.1ORCID,Patrician Alexander1ORCID,Tremblay Joshua C.1ORCID,Panerai Ronney B.4ORCID,Robinson Thompson G.4,Minhas Jatinder S.4ORCID,Ainslie Philip N.1

Affiliation:

1. Centre for Heart, Lung and Vascular Health School of Health and Exercise Sciences University of British Columbia Okanagan Kelowna BC Canada

2. Department of Anesthesiology Pharmacology and Therapeutics Vancouver General Hospital University of British Columbia Vancouver BC Canada

3. Department of Cellular and Physiological Sciences University of British Columbia Vancouver BC Canada

4. Cerebral Haemodynamics in Ageing and Stroke Medicine (CHIASM) Research Group Leicester Biomedical Research Centre University of Leicester Leicester UK

Funder

Canada Research Chairs

Dunhill Medical Trust

Publisher

Wiley

Subject

Physiology

Reference102 articles.

1. Infusion of sodium bicarbonate in experimentally induced metabolic acidosis does not provoke cerebrospinal fluid (CSF) acidosis in calves;Abeysekara S;Can J Vet Res,2012

2. Fast bicarbonate-chloride exchange between plasma and brain extracellular fluid at maintained $$P_{CO_2 } $$

3. Integration of cerebrovascular CO2reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation

4. Intracellular pH of brain: alterations in acute respiratory acidosis and alkalosis

5. Systemic effects of NaHCO3 in experimental lactic acidosis in dogs;Arieff AI;Am J Physiol,1982

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