Functional stability of CFTR depends on tight binding of ATP at its degenerate ATP‐binding site-Reference-Cited by-同舟云学术

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Functional stability of CFTR depends on tight binding of ATP at its degenerate ATP‐binding site

Published:2021-09-17 Issue:20 Volume:599 Page:4625-4642
ISSN:0022-3751
Container-title:The Journal of Physiology
language:en
Short-container-title:J Physiol

Author:

Yeh Han‐I¹²^ORCID,Yu Ying‐Chun¹,Kuo Pei‐Lun³,Tsai Chun‐Kuang³,Huang Hsin‐Tuan³,Hwang Tzyh‐Chang¹²^ORCID

Affiliation:

1. Dalton Cardiovascular Research Center and Department of Medical Pharmacology and Physiology University of Missouri‐Columbia Columbia MO 65211 USA

2. Department of Pharmacology School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan

3. School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan

Funder

National Institutes of Health

Cystic Fibrosis Foundation

Ministry of Science and Technology, Taiwan

Publisher

Wiley

Subject

Physiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1113/JP281933

Reference68 articles.

1. Regulatory Insertion Removal Restores Maturation, Stability and Function of ΔF508 CFTR

2. Allosteric Modulation Balances Thermodynamic Stability and Restores Function of ΔF508 CFTR

3. The First Nucleotide Binding Domain of Cystic Fibrosis Transmembrane Conductance Regulator Is a Site of Stable Nucleotide Interaction, whereas the Second Is a Site of Rapid Turnover

4. Prolonged Nonhydrolytic Interaction of Nucleotide with CFTR's NH2-terminal Nucleotide Binding Domain and its Role in Channel Gating

5. Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

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1. Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore;Nature Communications;2024-08-06

2. Two rare variants that affect the same amino acid in CFTR have distinct responses to ivacaftor;The Journal of Physiology;2024-01

3. Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Targeted Therapeutics for Cystic Fibrosis;Ion Channels as Targets in Drug Discovery;2024

4. A transistor model for the cystic fibrosis transmembrane conductance regulator;Biophysical Reports;2023-06

5. CFTR function, pathology and pharmacology at single-molecule resolution;Nature;2023-03-22

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