Interstitial IgG antibody pharmacokinetics assessed by combinedin vivo- and physiologically-based pharmacokinetic modelling approaches

Author:

Eigenmann Miro J.12ORCID,Karlsen Tine V.2,Krippendorff Ben-Fillippo1,Tenstad Olav2,Fronton Ludivine1,Otteneder Michael B.1,Wiig Helge2

Affiliation:

1. Roche Pharma Research and Early Development; Pharmaceutical Sciences; Roche Innovation Centre Basel; Switzerland

2. Department of Biomedicine; University of Bergen; Norway

Funder

Norges Forskningsråd

Publisher

Wiley

Subject

Physiology

Reference40 articles.

1. Interstitial-lymphatic mechanisms in the control of extracellular fluid volume;Aukland;Physiol Rev,1993

2. Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice;Baxter;Cancer Res,1994

3. Compartmental tissue distribution of antibody therapeutics: experimental approaches and interpretations;Boswell;AAPS J,2012

4. Comparative physiology of mice and rats: radiometric measurement of vascular parameters in rodent tissues;Boswell;Mol Pharm,2014

5. Physiological parameter values for physiologically based pharmacokinetic models;Brown;Toxicol Ind Health,1997

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