Artesunate attenuates airway resistance in vivo and relaxes airway smooth muscle cells in vitro via bitter taste receptor‐dependent calcium signalling

Author:

Wang Yue12,Wang Aili12,Zhang Ming3,Zeng Huilong1,Lu Yun1,Liu Lei1,Li Jingjing1,Deng Linhong12ORCID

Affiliation:

1. Changzhou Key Laboratory of Respiratory Medical EngineeringInstitute of Biomedical Engineering and Health SciencesChangzhou University Changzhou Jiangsu 213164 China

2. School of Pharmaceutical Engineering and Life Science & School of NursingChangzhou University Changzhou Jiangsu 213164 China

3. Department of Thoracic and Cardiovascular SurgeryChangzhou No. 2 People's HospitalAffiliated to Nanjing Medical University Changzhou Jiangsu 213003 China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Physiology,Physiology (medical),Nutrition and Dietetics

Reference42 articles.

1. TAS2R activation promotes airway smooth muscle relaxation despite β2‐adrenergic receptor tachyphylaxis;An S. S.;American Journal of Physiology. Lung Cellular & Molecular Physiology,2012

2. Signaling and regulation of G protein‐coupled receptors in airway smooth muscle;Billington C. K.;Respiratory Research,2003

3. T2Rs function as bitter taste receptors;Chandrashekar J.;Cell,2000

4. IL‐21 does not involve in OVA‐induced airway remodeling and chronic airway inflammation;Chen H.;International Journal Clinical Experiment Medicine,2015

5. Anti‐malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3‐kinase/Akt pathway;Cheng C.;PLoS ONE,2011

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