CrossTalk proposal: The late sodium current is an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction)
Author:
Affiliation:
1. Department of Anesthesiology; Pharmacology and Therapeutics; University of British Columbia; Vancouver British Columbia Canada
2. Department of Biology; Cardiovascular Therapeutic Area; Gilead Sciences; Foster City CA USA
Publisher
Wiley
Subject
Physiology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1113/jphysiol.2013.262261/fullpdf
Reference32 articles.
1. Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat;Aistrup;Am J Physiol Heart Circ Physiol,2013
2. A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias;Belardinelli;J Pharmacol Exp Ther,2013
3. Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment;Borlaug;Eur Heart J,2011
4. Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy;Coppini;Circulation,2013
5. Mouse models of SCN5A-related cardiac arrhythmias;Derangeon;Front Physiol,2012
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3. Scn1b expression in the adult mouse heart modulates Na+ influx in myocytes and reveals a mechanistic link between Na+ entry and diastolic function;American Journal of Physiology-Heart and Circulatory Physiology;2022-06-01
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