Phosphorylation of cardiac sodium channel at Ser571 anticipates manifestations of the aging myopathy-Reference-Cited by-同舟云学术

Phosphorylation of cardiac sodium channel at Ser571 anticipates manifestations of the aging myopathy

Published:2024-06-01 Issue:6 Volume:326 Page:H1424-H1445
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Pizzo Emanuele¹^ORCID,Cervantes Daniel O.¹,Ketkar Harshada²,Ripa Valentina¹,Nassal Drew M.³⁴,Buck Benjamin⁵,Parambath Sreema P.²,Di Stefano Valeria¹,Singh Kanwardeep¹,Thompson Carl I.¹,Mohler Peter J.³⁵⁶,Hund Thomas J.³⁴⁵,Jacobson Jason T.¹⁷,Jain Sudhir²^ORCID,Rota Marcello¹^ORCID

Affiliation:

1. Department of Physiology, New York Medical College, Valhalla, New York, United States

2. Department of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, New York, United States

3. The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States

4. Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, United States

5. Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States

6. Department of Physiology and Cell Biology, The Ohio State University College of Medicine, Columbus, Ohio, United States

7. Department of Cardiology, Westchester Medical Center, Valhalla, New York, United States

Abstract

We have investigated the impact of the late Na current ( INa,L) on cardiac and myocyte function with aging by using genetically engineered animals with enhanced or stabilized INa,L, due to phosphomimetic or phosphoablated mutations of Nav1.5. Our findings support the notion that phosphorylation of Nav1.5 at Ser571 prolongs myocardial repolarization and impairs diastolic function, contributing to the manifestations of the aging myopathy.

Funder

University of Parma

American Heart Association

HHS | National Institutes of Health

New York Medical College

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00325.2023

Reference66 articles.

1. Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

2. Colby SL, Ortman JM. Projections of the Size and Composition of the U.S. Population: 2014 to 2060, Current Population Reports, P25-1143. Washington DC: Census Bureau, 2014.

3. Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises

4. Targeting Age-Related Pathways in Heart Failure

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