Adjuvant PD-1 Blockade in Resected Melanoma: Is Preventing Recurrence Enough?-Reference-Cited by-同舟云学术

Adjuvant PD-1 Blockade in Resected Melanoma: Is Preventing Recurrence Enough?

Published:2022-03-01 Issue:3 Volume:12 Page:599-601
ISSN:2159-8274
Container-title:Cancer Discovery
language:en
Short-container-title:

Author:

Smithy James W.¹,Shoushtari Alexander N.¹²^ORCID

Affiliation:

1. 1Memorial Sloan Kettering Cancer Center, New York, New York.

2. 2Weill Cornell Medical College, New York, New York.

Abstract

Summary: Grossmann and colleagues report the results of a large randomized trial demonstrating improved recurrence-free survival with adjuvant pembrolizumab in resected melanoma compared with adjuvant ipilimumab or IFNα2b. However, it remains unclear whether adjuvant immunotherapies extend overall survival as outcomes for patients with advanced melanoma continue to improve. See related article by Grossmann et al., p. 644 (1).

Publisher

American Association for Cancer Research (AACR)

Subject

Oncology

Link

https://aacrjournals.org/cancerdiscovery/article-pdf/12/3/599/3052848/599.pdf

Reference9 articles.

1. Adjuvant pembrolizumab versus IFNα2b or ipilimumab in resected high-risk melanoma;Grossmann;Cancer Discov,2022

2. Longer follow-up confirms recurrence-free survival benefit of adjuvant pembrolizumab in high-risk stage III melanoma: updated results from the EORTC 1325-MG/KEYNOTE-054 trial;Eggermont;J Clin Oncol,2020

3. Adjuvant nivolumab versus ipilimumab in resected stage IIIB-C and stage IV melanoma (CheckMate 238): 4-year results from a multicentre, double-blind, randomised, controlled, phase 3 trial;Ascierto;Lancet Oncol,2020

4. Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684;Kirkwood;J Clin Oncol,1996

5. A pooled analysis of eastern cooperative oncology group and intergroup trials of adjuvant high-dose interferon for melanoma;Kirkwood;Clin Cancer Res,2004

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