Glioma Response to IDH Inhibition: Real-World Experience-Reference-Cited by-同舟云学术

Glioma Response to IDH Inhibition: Real-World Experience

Published:2023-09-22 Issue:23 Volume:29 Page:4709-4710
ISSN:1078-0432
Container-title:Clinical Cancer Research
language:en
Short-container-title:

Author:

Lukas Rimas V.¹²^ORCID,Horbinski Craig²³⁴^ORCID

Affiliation:

1. 1Department of Neurology, Northwestern University, Chicago, Illinois.

2. 2Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, Illinois.

3. 3Department of Neurological Surgery, Northwestern University, Chicago, Illinois.

4. 4Department of Pathology, Northwestern University, Chicago, Illinois.

Abstract

SummaryTreatment of IDH-mutated non-enhancing grade 2 and 3 diffuse gliomas with ivosidenib leads to reduction of tumor size when assessed via volumetric MRI. Isocitrate dehydrogenase inhibition has a therapeutic benefit in patients with these tumors.See related article by Kamson et al., p. 4863

Funder

National Cancer Institute

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Link

https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-23-2164/3366382/ccr-23-2164.pdf

Reference12 articles.

1. Impact of frontline ivosidenib on volumetric growth patterns in isocitrate dehydrogenase–mutant astrocytic and oligodendroglial tumors;Kamson;Clin Cancer Res,2023

2. Isocitrate dehydrogenase (IDH) mutant gliomas: a Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions;Miller;Neuro Oncol,2023

3. Modeling the diffusion of D-2-hydroxyglutarate from IDH1 mutant gliomas in the central nervous system;Linninger;Neuro Oncol,2018

4. Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma: a randomized perioperative phase I trial;Mellinghoff;Nat Med,2023

5. In vivo 2-hydroxyglutarate monitoring with edited MR spectroscopy for the follow-up of IDH-mutant diffuse gliomas: The IDASPE Prospective Study;Di Stefano;Neurology,2023

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