Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions

Author:

Miller Julie J12,Gonzalez Castro L Nicolas234ORCID,McBrayer Samuel5,Weller Michael6ORCID,Cloughesy Timothy7,Portnow Jana8,Andronesi Ovidiu29,Barnholtz-Sloan Jill S10,Baumert Brigitta G11,Berger Mitchell S12ORCID,Bi Wenya Linda213,Bindra Ranjit14ORCID,Cahill Daniel P15ORCID,Chang Susan M12,Costello Joseph F12,Horbinski Craig161718ORCID,Huang Raymond Y219,Jenkins Robert B20ORCID,Ligon Keith L221,Mellinghoff Ingo K22,Nabors L Burt23,Platten Michael24,Reardon David A234,Shi Diana D225,Schiff David26,Wick Wolfgang27ORCID,Yan Hai28,von Deimling Andreas29,van den Bent Martin30,Kaelin William G231,Wen Patrick Y234

Affiliation:

1. Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital , Boston, MA , USA

2. Harvard Medical School , Boston, MA , USA

3. Center for Neuro-Oncology, Dana-Farber Cancer Institute , Boston, MA , USA

4. Department of Neurology, Brigham and Women’s Hospital , Boston, MA , USA

5. Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center , 6000 Harry Hines Blvd, Dallas, Texas, 75235 , USA

6. Department of Neurology, University Hospital Zurich , Frauenklinikstrasse 26, 8091 Zurich , Switzerland

7. UCLA Neuro-Oncology Program , Los Angeles, CA , USA

8. Oncology, City of Hope Comprehensive Cancer Center , Duarte, CA , USA

9. Department of Radiology, Massachusetts General Hospital , Boston, MA , USA

10. Informatics and Data Science (IDS), Center for Biomedical Informatics and Information Technology (CBIIT), Trans-Divisional Research Program (TDRP), Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI) , Bethesda, MD , USA

11. Cantonal Hospital Graubunden, Institute of Radiation-Oncology , Chur , Switzerland

12. Department of Neurosurgery, University of California-San Francisco , San Francisco, California , USA

13. Department of Neurosurgery, Brigham and Women’s Hospital , Boston, MA , USA

14. Department of Therapeutic Radiology, Brain Tumor Center, Yale School of Medicine , New Haven, CT , USA

15. Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts , USA

16. Department of Pathology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois , USA

17. Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University , Chicago, Illinois , USA

18. Northwestern Medicine Malnati Brain Tumor Institute of the Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University , Chicago, Illinois , USA

19. Department of Radiology, Brigham and Women’s Hospital , Boston, Massachusetts , USA

20. Individualized Medicine Research, Mayo Clinic, Department of Laboratory Medicine and Pathology , Rochester, Minnesota 55901 , USA

21. Department of Pathology, Brigham and Women’s Hospital , Boston, Massachusetts , USA

22. Department of Neurology, Evnin Family Chair in Neuro-Oncology, Memorial Sloan Kettering Cancer Center , New York, New York , USA

23. Department of Neurology, Heersink School of Medicine, The University of Alabama at Birmingham , Birmingham, Alabama , USA

24. CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ) , Im Neuenheimer Feld 280, 69120 Heidelberg , Germany

25. Department of Radiation Oncology, Brigham and Women’s Hospital , Boston, Massachusetts , USA

26. Division of Neuro-Oncology, Department of Neurology, University of Virginia Health System , Charlottesville, Virginia , USA

27. Neuro-Oncology at the German Cancer Research Center (DKFZ), Program Chair of Neuro-Oncology at the National Center for Tumor Diseases (NCT), and Neurology and Chairman at the Neurology Clinic in Heidelberg , Heidelberg, Germany

28. Genetron Health Inc , Gaithersburg, Maryland 20879 , USA

29. Department of Neuropathology, University Hospital Heidelberg, and, Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), and, DKTK, INF 224 , 69120 Heidelberg , Germany

30. Brain Tumour Centre, Erasmus MC Cancer Institute , Groene Hilledijk 301, 3075 EA Rotterdam , The Netherlands

31. Department of Medical Oncology, Dana-Farber Cancer Institute , Boston, Massachusetts , USA

Abstract

Abstract Isocitrate dehydrogenase (IDH) mutant gliomas are the most common adult, malignant primary brain tumors diagnosed in patients younger than 50, constituting an important cause of morbidity and mortality. In recent years, there has been significant progress in understanding the molecular pathogenesis and biology of these tumors, sparking multiple efforts to improve their diagnosis and treatment. In this consensus review from the Society for Neuro-Oncology (SNO), the current diagnosis and management of IDH-mutant gliomas will be discussed. In addition, novel therapies, such as targeted molecular therapies and immunotherapies, will be reviewed. Current challenges and future directions for research will be discussed.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Neurology (clinical),Oncology

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